个人简介

江苏省特聘教授，江苏省”双创”人才，南京医科大学特聘教授(A类)。2006年于吉林大学白求恩医学部博士研究生毕业后，在美国犹他大学肾脏病科学习（博士后）和工作10余年，历任研究助理及助理教授（研究型）。本人一直致力于肾脏水盐代谢调控及肾脏损伤修复的研究工作。近10年在Journal of the American Society of Nephrology （IF：9.34）、Acta Physiologica （IF：5.93）、 American Journal of Physiology（IF：3.6）等SCI杂志发表论文50余篇（IF>200），论文被Faculty of 1000推荐。是SCI杂志Frontiers in Physiology （IF：3.39）、Scientific Reports (IF:4.122)的编委及学术编辑，PPAR Research （IF：4.186）特约客座编辑，10余个SCI杂志的审稿专家，国家自然科学基金评审专家。任Faculty of 1000 的Associate Faculty。

研究方向

肾脏的水盐代谢，急慢性肾脏损伤的发病机制及干预研究

主持科研项目或人才项目

1.NMIIA/MG53 通路在 CKD肾小管间质纤维化中的作用及机制研究（81770690），国家自然科学基金面上项目，2018-2021，56万元

2.江苏省特聘教授科研资助基金，2016-2019， 250万元

3.调控炎症小体与线粒体的病理性对话：干预足细胞损伤的新靶标（81570616），国家自然科学基金面上项目，2016-2019，57万元

代表性论文

1.Genetic Deletion of ADP-activated P2Y12 Receptor Ameliorates Lithium-induced Nephrogenic Diabetes Insipidus in Mice. Acta Physiol (Oxf). 2019，Feb;225(2):e13191.

2.Prostaglandins in the pathogenesis of kidney diseases. Oncotarget. 2018 May 29;9(41):26586-26602. 

3.Targeting PPARα For The Treatment And Understanding Of Cardiovascular Diseases. Cellular Physiology and Biochemistry.2018;51:2760-2775. 

4.Genetic Deletion of P2Y2 Receptor Offers Long-Term (5 Months) Protection Against Lithium-Induced Polyuria, Natriuresis, Kaliuresis, and Collecting Duct Remodeling and Cell Proliferation. Frontiers in Physiology. 2018 Dec 17;9:1765.

5.mPGES-1-Derived PGE2 Contributes to Indoxyl Sulfate-Induced Mesangial Cell Proliferation. Cell Physiol Biochem. 2017;43(1):271-281.

6.MnTBAP therapy attenuates the downregulation of sodium transporters in obstructive kidney disease. Oncotarget. 2017 Dec 7;9(1):394-403.

7.Prasugrel suppresses development of lithium-induced nephrogenic diabetes insipidus in mice. Purinergic Signal. 2017 Jun;13(2):239-248.

8.Inhibition of Mitochondrial Complex-1 Restores the Downregulation of Aquaporins in Obstructive Nephropathy. Am J Physiol Renal Physiol. 2016,311(4): F777-F786.

9.P2Y12 Receptor Localizes in the Renal Collecting, Duct and Its Blockade Augments Arginine Vasopressin Action and Alleviates Nephrogenic Diabetes Insipidus. J Am Soc Nephrol, 2015; 26(12):2978-2987. 

10.Role of COX-2/mPGES-1/Prostaglandin E2 Cascade in Kidney Injury. Mediators Inflamm, 2015:147894.

11.Clopidogrel attenuates lithium-induced alterations in renal water and sodium channels/transporters in mice. Purinergic Signaling 2015, 11(4):507-518.

12.Inhibition of Mitochondrial Complex-1 Prevents the Downregulation of NKCC2 and ENaCα in Obstructive Kidney Disease. Sci Rep. 2015 Jul 24;5:12480.

13.Impaired natriuretic response to high-NaCl diet plus aldosterone infusion in mice overexpressing human CD39, an ectonucleotidase (NTPDase1). Am J Physiol Renal Physiol. 2015;308(12):F1398-408.

14.Rotenone Remarkably Attenuates Oxidative Stress, Inflammation, and Fibrosis in Chronic Obstructive Uropathy. Mediators Inflamm. 2014;2014:670106. 

15.New Insights into the PPAR γ Agonists for the Treatment of Diabetic Nephropathy. PPAR Res. 2014;2014:818530.

16.Attenuation of Lithium-induced Natriuresis and Kaliuresis in P2Y2 Receptor Knockout Mice. Am J Physiol Renal Physiol. 2013;305(3):F407-416.

17.Defective Renal Water Handling in Transgenic Mice Over-expressing Human CD39/NTPDase1. Am J Physiol Renal Physiol. 2012;303(3):F420-F430.

18.Genetic Deletion of P2Y2 Receptor Offers Significant Resistance for the Development of Lithium-induced Polyuria Accompanied with Alterations in PGE2 Signaling. Am J Physiol Renal Physiol. 2012;302(1):F70-F77,

19.Renal sodium transporter/channel expression and sodium excretion in P2Y2 receptor knockout mice fed a high-NaCl diet with/without aldosterone infusion. Am J Physiol Renal Physiol. 2011;300(3): F657-568.

20.Potential involvement of P2Y2   receptor in diuresis of postobstructive uropathy in rats. Am J Physiol Renal Physiol. 2010;298(3):F634-42. 

21.Potential Role of Purinergic Signaling in Lithium-induced Nephrogenic Diabetes Insipidus. Am J Physiol Renal Physiol. 2009;296(5): F1194-201.

22.Potential role of purinergic signaling in urinary concentration in inner medulla: insights from P2Y2 receptor gene knockout mice. Am J Physiol Renal Physiol. 2008;295(6): F1715-24.

授权专利

1.发明专利：鱼藤酮用于治疗动脉粥样硬化的用途。专利号：ZL201611094922.9 ，授权日日：2019年9月6日

2.实用新型专利：一种通过检测尿液miR-214来预测肾脏纤维化程度的试剂盒，专利号：ZL1821108928.1，授权日：2019年7月19日

3.发明专利：鱼藤酮在胰导保护中的作用，专利号：ZL201810725780.4，授权日： 2019年04月12日

4.美国发明专利（已授权）Methods and Compositions for Treating Acquired Nephrogenic Diabetes Insipidus. 专利号：US-9539246，授权日：2017年1月10日