Scientific Research
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医学博士
助理研究员
个人简介
2012年9月进入南京医科大学儿科学硕博连读,师从张爱华教授,期间参与多项国家自然科学基金,并独立主持校级创新课题,培养了研究能力与科研创新精神。2016年7月进入南京医科大学附属儿童医院重点实验室专职从事科研工作,并于2017年9月进入南京医科大学临床医学博士后流动站,合作导师为胡志斌教授和贾占军教授。工作期间以第一作者在Kidney International(IF:8.3)、Am J Physiol Renal Physiol(IF:3.3)等杂志发表SCI论文多篇,是Frontiers Physiology、Plos one、Scientific reports 等SCI期刊审稿专家。
主持科研项目
1.Lonp1:足细胞损伤干预的新靶标(JQX18007),南京市科技发展杰出青年项目,2019.1-2021.12,50万
2.Lonp1在足细胞损伤中的作用及机制研究(2018M632341),中国博士后基金面上项目,2018.6-2020.6,5万
3.MUTYH在急性肾小管损伤中的作用及机制研究(81700595),国家自然科学基金青年科学基金,2018.01-2020.12,20 万
代表性论文
1.Bai M#, Chen H#, Ding D, Song R, Lin J, Zhang Y, Guo Y, Chen S, Ding G, Zhang Y, Jia Z, Huang S, He JC, Yang L, Zhang A*. MicroRNA-214 promotes chronic kidney disease by disrupting mitochondrial oxidative phosphorylation. Kidney Int. 2019 Jun;95(6):1389-1404.
2.Mi Bai#, Luan Lei#, Shuqin Wang, Dan Ding, Xiaowen Yu, Yan Guo, Shuang Chen, Yang Du, Deyi Li, Yue Zhang, Songming Huang, Zhanjun Jia*, Aihua Zhang*. BMP1 inhibitor UK-383,367 attenuates renal fibrosis and inflammation in CKD, Am J Physiol Renal Physiol, 2019, 317(6): 1430-1438.
3.Zhao M#, Bai M#, Ding G, Zhang Y, Huang S, Jia Z, Zhang A.*Angiotensin II Stimulates the NLRP3 Inflammasome to Induce Podocyte Injury and Mitochondrial Dysfunction. Kidney Dis (Basel). 2018 Jun;4(2):83-94.
4.Bai Mi#, Chen Ying#, Zhao Min, Zhang Yue, He John Ci-Jiang, Huang Songming, Jia Zhanjun*, Zhang Aihua, NLRP3 Inflammasome Activation Contributes to Aldosterone-induced Podocyte Injury, Am J Physiol Renal Physiol, 2017 Apr 1;312(4):F556-F564.
5.ai Mi#, Che Ruochen#, Zhang Yue, Yuan Yanggang, Zhu Chunhua, Ding Guixia, Jia Zhanjun, Huang Songming, Zhang Aihua*, Reactive Oxygen Species-Initiated Autophagy Opposes Aldosterone-Induced Podocyte Injury, Am J Physiol Renal Physiol, 2016, 310:669-678.
6.Guo Y#, Ni J#, Chen S, Bai M, Lin J, Ding G, Zhang Y, Sun P, Jia Z, Huang S, Yang L, Zhang A*. MicroRNA-709 Mediates Acute Tubular Injury through Effects on Mitochondrial Function. J Am Soc Nephrol. 2018 Feb;29(2):449-461.
7.Guo Y#, Deng X#, Chen S, Yang L, Ni J, Wang R, Lin J, Bai M, Jia Z, Huang S, Zhang A*. MicroRNA-30e targets BNIP3L to protect against aldosterone-induced podocyte apoptosis and mitochondrial dysfunction. Am J Physiol Renal Physiol. 2017 Apr 1;312(4):F589-F598.
8.Zhao M, Yuan Y, Bai M, Ding G, Jia Z, Huang S, Zhang A*.PGC-1α overexpression protects against aldosterone-induced podocyte depletion: role of mitochondria. Oncotarget. 2016 Mar 15;7(11):12150-12562.
9.Che R, Zhu C, Ding G, Zhao M, Bai M, Jia Z, Zhang A, Huang S*. Huaier Cream Protects against Adriamycin-Induced Nephropathy by Restoring Mitochondrial Function via PGC-1α Upregulation. PPAR Res. 2015;2015:720383.
10.Zhuang Yibo, Ding Guixia, Zhao Min, Bai Mi, Yang Lingyun, Ni Jiajia, Wang Rong, Jia Zhanjun, Huang Songming, Zhang Aihua*, NLRP3 inflammasome mediates albumin-induced renal tubular injury through impaired mitochondrial function, J Biol Chem. 2014, 289(36):25101-25111.
授权专利
1.实用新型专利:一种通过检测尿液miR-214来预测肾脏纤维化程度的试剂盒。专利号:ZL201821108928.1,授权日:2019年7月19日。发明人:张爱华,白咪,贾占军,张玥,黄松明,郭燕,陈爽,杜阳
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