个人简介

2016年8月毕业于南京大学生命科学学院，并获药学博士学位，2016年9月进入南京市儿童医院儿科重点实验室从事科研工作，目前主要从事儿童疾病相关的基础研究工作。已发表一作和共同一作SCI文章9篇，第一作者文章已被引用90余次。

主持科研项目

1.DNA-PKcs在蛋白尿诱导的肾小管损伤中的作用及机制研究（2018M640505），中国博士后基金，2018.11-2020.11，8万

2.FADD在肾小管间质纤维化中的作用及机制研究（2018K042A），江苏省博士后基金，2018.9-2020.9，8万

3.FADD负性调控细胞自噬：脂质导致肾小管损伤的新机制（81700642），国家自然科学基金青年基金，2018.1-2020.12，20万

4.FADD在脂质引起的肾小管损伤中的作用及机制研究(BK20170150)，江苏省自然科学基金，2017.7-2020.7, 20万

5.NM IIA在肾间质成纤维细胞活化中的作用及机制研究(2016NJMV102)，南京医科大学科学基金面上项目，2017.1-2018.12，1万元

已发表文章

1.Yunwen Yang#, Suwen Liu#, Huiping Gao, Peipei Wang, Yue Zhang, Aihua Zhang*, Zhanjun Jia*, and Songming Huang*. Ursodeoxycholic acid protects against cisplatin-induced acute kidney injury and mitochondrial dysfunction through acting on ALDH1L2. Free Radic Biol Med. 2020;152:821-837.

2.Suwen Liu#,Yunwen Yang#, Huiping Gao, Ning Zhou, Peipei Wang, Yue Zhang, Aihua Zhang, Zhanjun Jia*, and Songming Huang*. Trehalose attenuates renal ischemia-reperfusion injury by enhancing autophagy and inhibiting oxidative stress and inflammation. Am J Physiol Renal Physiol. 2020;318(4):F994-F1005.

3.Yunwen Yang, Yu Fu, Peipei Wang, Suwen Liu, Yugen Sha, Yue Zhang, Zhangjun Jia, Aihua Zhang, Guixia Ding*, and Songming Huang*. Intervention of Mitochondrial Activity Attenuates Cisplatin-induced Acute Kidney Injury. International Urology and Nephrology. 2019;51(7):1207-1218.

4.Wen Zhang#, Yunwen Yang#, Huiping Gao, Yue Zhang, Zhanjun Jia*, Songming Huang*. Inhibition of mitochondrial complex I aggravates folic acid-induced acute kidney injury. kidney & blood pressure research. 2019. 44(5):1002-1013.

5.Yunwen Yang#, Xiaowen Yu#, Yue Zhang, Guixia Ding, Chunhua Zhu, Songming Huang, Zhanjun Jia*, and Aihua Zhang*. Hypoxia-inducible factor prolyl hydroxylase inhibitor roxadustat (FG-4592) protects against cisplatin-induced acute kidney injury. clinical science (Lond). 2018;132(7):825-838. 

6.Xiaowen Yu#, Yunwen Yang#, Hui Yuan, Meng Wu, Shuzhen Li, Wei Gong, Jing Yu, Weiwei Xia, Yue Zhang, Guixia Ding, Songming Huang, Zhanjun Jia* and Aihua Zhang*. Inhibition of COX-2/PGE2 cascade ameliorates cisplatin-induced mesangial cell apoptosis. American Journal of Translational Research. 2017;9(3):1222-1229.

7.Yunwen Yang, Mangkun Chen, Bingya Yang, Xianjie Huang, Xuerui Zhang, Liangqiang He, Jing Zhang* and Zichun Hua*. Use of 16S rRNA Gene-Targeted Group-Specific Primers for Real-Time PCR Analysis of Predominant Bacteria in Mouse Feces. Appl Environ Microbiol. 2015;81(19):6749-6756.Yunwen Yang, Chun-Mei Zhang, Xian-Jie Huang, Xiao-Xin Zhang, Lin-Kai Zhang and Zi-Chun Hua*. Tumor-targeted delivery of a C-terminally truncated FADD (N-FADD) significantly suppresses the B16F10 melanoma via enhancing apoptosis. Scientific reports. 2016;6:34178.

8.Xi Luo#, Yunwen Yang#, Wen Ling, Hao Zhuang, Qin Li and Guangdong Shang*. Pseudomonas putida KT2440 markerless gene deletion using a combination of lambda Red recombineering and Cre/loxP site-specific recombination. FEMS Microbiol Lett 2016;363(4) fnw014. 

9.Zhuang Hongqin, Xueshi Wang, Daolong Zha, Ziyi Gan, Fangfang Cai, Pan Du, Yunwen Yang, Bingya Yang, Xiangyu Zhang, Chun Yao, Yuqiang Zhou, Chizhou Jiang, Shenwen Guan, Xiaoxin Zhang, Jing Zhang, Weiwei Jiang, Qingang Hu and Zichun Hua*. FADD is a key regulator of lipid metabolism. EMBO Mol Med 2016;8(8):895-918.

授权专利

1.发明专利：恶臭假单胞菌KT2440高效的基因敲除方法，专利号：102071185B，授权日期：2012年7月4日，发明人：尚广东、杨运文、宋杰、高九彩