个人简介

2012-2017年就读于南京大学医学院基础医学专业，硕士及博士期间从事复杂性疾病的遗传机制研究,主要研究课题为中国人ABCA3和MUTYH基因变异与特发性肺纤维化的遗传基础研究。本人一直从事单基因遗传性疾病基因诊断及相关实验技术方面工作，重点研究激素耐药型肾病综合征新致病基因的挖掘及机制研究。目前主持国家自然科学基金青年项目（81800652）、江苏省博士后科研资助项目（2019K156）、中国博士后科学基金面上资助项目（229906）各1项，参与国家自然科学基金面上项目2项。在遗传性疾病方面发表SCI论文多篇，其中第一作者论著3篇，综述1篇。参与申报发明专利1项。现为中国病理学会会员，江苏省医学会罕见病学分会秘书，plos one杂志审稿人。

主持科研项目

1.MAVS在终末期肾病相关的血管内皮损伤中的作用及机制研究(81800652)国家自然科学基金青年项目，2019.01-2021.12，20万元

2.儿童激素耐药型肾病综合征/局灶节段性肾小球硬化新致病基因的鉴定及功能研究（2019K156），“江苏省博士后科研资助计划”B类资助，5万元

3.KIF13B基因突变在儿童激素耐药肾病综合征中的作用（229906），中国博士后科学基金面上资助二等，8万元

代表性论文

1.Bixia Zheng, Qiuxia Chen, Chunli Wang, Wei Zhou, Ying Chen, Guixia Ding, Zhanjun Jia, Aihua Zhang, Songming Huang. Whole-genome sequencing revealed an interstitial deletion encompassing OCRL and SMARCA1 gene in a patient with LOWE syndrome. Mol Genet Genomic Med. 2019 Aug 3:e876.

2.Wei Zhou, Jiapeng Sun, Wenwen Guo*, Yi Zhuang, Lizhi Xu, Yaping Wang*. AluYb8 insertion polymorphism in the MUTYH gene impairs mitochondrial DNA maintenance and affects the age of onset of IPF. Aging (Albany NY). 2019;11(3):933-949.

3.Wang, Chunli#; Zhou, Wei#; Huang, Yan; Yin, Hanjun; Jin, Yu; Jia, Zhanjun; Zhang, Aihua; Liu, Zhifeng; Zheng, Bixia*, Presumed missense and synonymous mutations in ATP7B gene cause exon skipping in Wilson disease., Liver international. 2018;38(8): 1504-1513.

4.Wei Zhou, Yi Zhuang, Jiapeng Sun, Xiaofen Wang, Qingya Zhao, Lizhi Xu*, Yaping Wang*, Variants of the ABCA3 gene might contribute to susceptibility to interstitial lung diseases in the Chinese population, Scientific reports. 2017;7: 4097.

5.Wei Zhou, Yaping Wang*, Candidate genes of idiopathic pulmonary fibrosis: current evidence and research, The application of clinical genetics. 2016, 9: 5-12

6.Cao, L., Zhou, W., Zhu, Y., Guo, W., Cai, Z., He, X., Xie, Y., Li, X., Zhu, D., and Wang, Y. Combined analysis of polymorphism variants in hMTH1, hOGG1 and MUTYH genes on the risk of type 2 diabetes in the Chinese population. Gene 2013; 519:50-54.

7.Li, X.X., Xu, L.Z., Zhou, W., Zhao, Q.Y., and Wang, Y.P. Chronic exposure to microcystin-LR affected mitochondrial DNA maintenance and caused pathological changes of lung tissue in mice. Environ Pollut. 2016;210:48-56.

8.Li, X., Zhao, Q., Zhou, W., Xu, L., and Wang, Y. Effects of chronic exposure to microcystin-LR on hepatocyte mitochondrial DNA replication in mice. Environ Sci Technol .2015;49: 4665-4672.

9.Cao, L., Li, T., Zhu, Y., Zhou, W., Guo, W., Cai, Z., Xie, Y., He, X., Li, X., Zhu, D., et al. Detection of mosaicism for the polymorphic variants in the 5'-UTR of hOGG1 by cloning and sequence analysis and pyrosequencing. Electrophoresis 2013;34: 1163-1170.

授权专利

1.发明专利：4-苯基丁酸钠盐在制备治疗I型Bartter综合征药物中的应用。申请号：201910656922.0；申请日：2019年7月19日；发明人：张爱华，王春莉，郑必霞，周玮，陈颖，韩媛，贾占军 , 沙玉根，于婧，公伟